An Apoferritin-based Drug Delivery System for the Tyrosine Kinase Inhibitor Gefitinib.
نویسندگان
چکیده
Anticancer drug Gefitinib encapsulated within human heavy chain apoferritin by diffusion allows pH-controlled sustained release of cargo. The combination of increased cellular uptake, and potent and enhanced antitumor activity against the HER2 overexpressing SKBR3 cell line compared to Gefitinib alone, makes it a promising carrier for delivery of drugs to tumor sites.
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ورودعنوان ژورنال:
- Advanced healthcare materials
دوره 4 18 شماره
صفحات -
تاریخ انتشار 2015